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Article

Pancreatic Pericytes Support β-Cell Function in a Tcf7l2-Dependent Manner.

Diabetes - 1 Mar 2018

Sakhneny Lina, Rachi Eleonor, Epshtein Alona, Guez Helen C, Wald-Altman Shane, Lisnyansky Michal, Khalifa-Malka Laura, Hazan Adina, Baer Daria, Priel Avi, Weil Miguel, Landsman Limor

Abstract excerpt

Polymorphism in TCF7L2, a component of the canonical Wnt signaling pathway, has a strong association with β-cell dysfunction and type 2 diabetes through a mechanism that has yet to be defined. β-Cells rely on cells in their microenvironment, including pericytes, for their proper function. Here, we show that Tcf7l2 activity in pancreatic pericytes is required for β-cell function. Transgenic mice in which Tcf7l2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29246974
DOI: 10.2337/db17-0697

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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