Article
Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration.
Scientific reports - 29 Aug 2017
Facchinello Nicola, Tarifeño-Saldivia Estefania, Grisan Enrico, Schiavone Marco, Peron Margherita, Mongera Alessandro, Ek Olivier, Schmitner Nicole, Meyer Dirk, Peers Bernard, Tiso Natascia, Argenton Francesco
Abstract excerpt
Type 2 diabetes (T2D) is a disease characterized by impaired insulin secretion. The Wnt signaling transcription factor Tcf7l2 is to date the T2D-associated gene with the largest effect on disease susceptibility. However, the mechanisms by which TCF7L2 variants affect insulin release from β-cells are not yet fully understood. By taking advantage of a tcf7l2 zebrafish mutant line, we first show that these animals...
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