TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals.

doi:10.1007/s00125-012-2660-8

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Article

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals.

Diabetologia - 1 Oct 2012

Le Bacquer O, Kerr-Conte J, Gargani S, Delalleau N, Huyvaert M, Gmyr V, Froguel P, Neve B, Pattou F

Abstract excerpt

AIMS/HYPOTHESIS: Transcription factor 7-like 2 (TCF7L2) is a Wnt-signalling-associated transcription factor. Genetic studies have clearly demonstrated that DNA polymorphisms within TCF7L2 confer the strongest known association with increased risk of type 2 diabetes. However, the impact of the TCF7L2 type-2-diabetes-associated rs7903146 T allele on biological function and morphology of human pancreatic islets is...

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PMID: 22911383
DOI: 10.1007/s00125-012-2660-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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