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Article

TCF7L2 splice variants have distinct effects on β-cell turnover and function

28 Feb 2011

Abstract excerpt

Type 2 diabetes manifests when the β-cell fails to secrete sufficient amounts of insulin to maintain normoglycemia and undergoes apoptosis. The disease progression results from an interplay of environmental factors and genetic predisposition. Polymorphisms in T-cell factor 7-like 2 (TCF7L2) strongly correlate with type 2 diabetes mellitus (T2DM). While TCF7L2 mRNA is upregulated in islets in diabetes, protein...

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PMID: 21357677
DOI: 10.1093/hmg/ddr072

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