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Article

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

Human molecular genetics - 1 Mar 2015

Mitchell Ryan K, Mondragon Angeles, Chen Lingling, Mcginty James A, French Paul M, Ferrer Jorge, Thorens Bernard, Hodson David J, Rutter Guy A, Da Silva Xavier Gabriela

Abstract excerpt

Type 2 diabetes (T2D) is characterized by β cell dysfunction and loss. Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D by genome-wide association studies, lead to impaired β cell function. While deletion of the homologous murine Tcf7l2 gene through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25355422
DOI: 10.1093/hmg/ddu553
PMCID: PMC4321446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25355422-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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