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Article

TCF7L2 and Glucose Metabolism: Time to Look Beyond the Pancreas

14 Feb 2013

Abstract excerpt

Noncoding genetic variation in the locus encod-ing for the Wnt signaling effector TCF7L2remains the strongest genetic determinant oftype 2 diabetes (T2D) risk in humans. This as-sociation raises the hypothesis that disease variants alter the quantitative, spatial, and/or temporal expression pat-terns of this gene. Understanding the mechanisms by which TCF7L2 and Wnt signaling regulate glucose metab-olism may...

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PMID: 23431017
DOI: 10.2337/db12-1418

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