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Article

Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.

Development (Cambridge, England) - 1 Jul 2016

Lan Yu, Zhang Nian, Liu Han, Xu Jingyue, Jiang Rulang

Abstract excerpt

Cleft palate is a common major birth defect for which currently known causes account for less than 30% of pathology in humans. In this study, we carried out mutagenesis screening in mice to identify new regulators of palatogenesis. Through genetic linkage mapping and whole-exome sequencing, we identified a loss-of-function mutation in the Golgb1 gene that co-segregated with cleft palate in a new mutant mouse...

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Identifiers

PMID: 27226319
DOI: 10.1242/dev.134577
PMCID: PMC4958322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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