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Article

Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28.

Human molecular genetics - 15 Aug 2011

Han Yanchao, Mu Yu, Li Xiaoquan, Xu Pengfei, Tong Jingyuan, Liu Zhaoting, Ma Tingting, Zeng Guodong, Yang Shuyan, Du Jiulin, Meng Anming

Abstract excerpt

Congenital and progressive hearing impairment is a common distressing disease. The progressive dominant hearing loss DFNA28 in human is associated with a frameshift mutation of Grainyhead-like 2 (GRHL2) but its etiology and mechanism remain unknown. Here we report a zebrafish grhl2b(T086) mutant line in which grhl2b expression is interrupted by an insertion of a Tol2 transposon element. The mutants exhibit...

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Identifiers

PMID: 21610158
DOI: 10.1093/hmg/ddr234

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GRHL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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