Article
The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension.
Developmental cell - 1 Aug 2001
Topczewski J, Sepich D S, Myers D C, Walker C, Amores A, Lele Z, Hammerschmidt M, Postlethwait J, Solnica-Krezel L
Abstract excerpt
Mutations in the zebrafish knypek locus impair gastrulation movements of convergent extension that narrow embryonic body and elongate it from head to tail. We demonstrate that knypek regulates cellular movements but not cell fate specification. Convergent extension movement defects in knypek are associated with abnormal cell polarity, as mutant cells fail to elongate and align medio-laterally. Positional cloning...
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