Article
Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2025
Mathiyalagan Nishanthi, Johnson Travis K, Di Pastena Zachary, Fuller Jarrad N, Miles Lee B, Dworkin Sebastian
Abstract excerpt
BACKGROUND: Environmental influence is critical for embryogenesis but is significantly under-appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead-like 3 (grhl3), a highly conserved gene that is pivotal in epithelial barrier...
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