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Article

Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding.

Journal of the American Chemical Society - 29 Mar 2017

Robotta Marta, Cattani Julia, Martins Juliana Cristina, Subramaniam Vinod, Drescher Malte

Abstract excerpt

The intrinsically disordered human protein alpha-Synuclein (αS) has a prominent role in Parkinson's disease (PD) pathology. Several familial variants of αS are correlated with inherited PD. Disease mutations have been shown to have an impact on lipid membrane binding. Here, using electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling, we show that familial PD-associated...

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PMID: 28298083
DOI: 10.1021/jacs.6b05335

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