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Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments.

eLife - 27 Jan 2020

Jackson Christopher A, Castro Dayanne M, Saldi Giuseppe-Antonio, Bonneau Richard, Gresham David

Abstract excerpt

Understanding how gene expression programs are controlled requires identifying regulatory relationships between transcription factors and target genes. Gene regulatory networks are typically constructed from gene expression data acquired following genetic perturbation or environmental stimulus. Single-cell RNA sequencing (scRNAseq) captures the gene expression state of thousands of individual cells in a single...

Topics

DNA Barcoding, Taxonomic
Gene Deletion
Gene Expression Regulation, Fungal
Gene Regulatory Networks
Genes, Fungal
Genotype
Saccharomyces cerevisiae
Sequence Analysis, RNA
Single-Cell Analysis
Transcription Factors

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PMID: 31985403
DOI: 10.7554/eLife.51254
PMCID: PMC7004572

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