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Article

Single-cell analyses identify independent aging processes that compete to determine cellular fate in budding yeast.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2026

Hotz Manuel, Kroll-Ling Rachel G, Thayer Nathaniel H, Gottschling Daniel E

Abstract excerpt

Phenotypic heterogeneity is prevalent during aging, yet its underlying molecular drivers remain poorly understood. In budding yeast, two distinct aging trajectories, characterized by either ribosomal DNA (rDNA) instability or mitochondrial decline, have been proposed to be mutually exclusive. Here, we systematically dissect the heterogeneity among aging yeast cells by combining single-cell transcriptomics with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41811451
DOI: 10.1073/pnas.2534452123
PMCID: PMC12993945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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