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Article

Differential promoter activities of functional haplotypes in the 5'-flanking region of human sulfotransferase 1A1.

Journal of biochemical and molecular toxicology - 1 Oct 2012

Lin Zhong-Ning, Lin Yu-Chun, Zhang Xuemei, Kadlubar Susan, Tuo Jingsheng, Green Bridgett, Deng Helen, Ning Baitang

Abstract excerpt

Previously, we reported five common single nucleotide polymorphisms (SNPs), -624G>C, -396G>A, -358A>C, -341C>G, and -294T>C, and six common haplotypes (CGACT, GAACT, GGAGC, GGACC, CAACT, and GAACC) in the 5'-flanking region of the SULT1A1 gene that were associated with altered enzymatic activity. In the present study, we performed in vitro assays to determine the functional impact of these genetic variations on...

Topics

5' Flanking Region
Arylsulfotransferase
Base Sequence
Cell Nucleus
Electrophoretic Mobility Shift Assay
Genes, Reporter
Genetic Association Studies
Haplotypes
Hep G2 Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Luciferases, Renilla

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Protein Binding

Transcriptional Activation

Source

Identifiers

PMID: 23080433
DOI: 10.1002/jbt.21437

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