Article
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Pharmacogenetics - 1 Aug 2003
Kroetz Deanna L, Pauli-Magnus Christiane, Hodges Laura M, Huang Conrad C, Kawamoto Michiko, Johns Susan J, Stryke Doug, Ferrin Thomas E, DeYoung Joseph, Taylor Travis, Carlson Elaine J, Herskowitz Ira, Giacomini Kathleen M, Clark Andrew G
Abstract excerpt
OBJECTIVES: There is increasing evidence that polymorphism of the ABCB1 (MDR1) gene contributes to interindividual variability in bioavailability and tissue distribution of P-glycoprotein substrates. The aim of the present study was to (1) identify and describe novel variants in the ABCB1 gene, (...
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