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Article

Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2006

Lang Thomas, Haberl Michael, Jung Diana, Drescher Anja, Schlagenhaufer Robert, Keil Andrea, Mornhinweg Esther, Stieger Bruno, Kullak-Ublick Gerd A, Kerb Reinhold

Abstract excerpt

Biliary excretion of bile salts and other bile constituents from hepatocytes is mediated by the apical (canalicular) transporters P-glycoprotein 3 (MDR3, ABCB4) and the bile salt export pump (ABCB11). Mutations in ABCB4 and ABCB11 contribute to cholestatic diseases [e.g., progressive familial intrahepatic cholestasis 2 (PFIC2), PFIC3, and intrahepatic cholestasis of pregnancy], and our objective was to establish...

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Share to ATP Binding Cassette Transporter, Subfamily B

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11

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Source

Identifiers

PMID: 16763017
DOI: 10.1124/dmd.105.008854

Genes

ABCB11
ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).PMID 16763017Read ↗

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