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Article

Haplotype-phenotype relationships of paraoxonase-1.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2005

Chen Jia, Chan Wendy, Wallenstein Sylvan, Berkowitz Gertrud, Wetmur James G

Abstract excerpt

Paraoxonase 1 (PON1) is an enzyme with multiple activities, including detoxification of organophosphates. It is believed to be important in preventing neurotoxic damage and has also been implicated in atherosclerosis. The PON1 gene contains five common polymorphisms, three in the promoter (-909G...

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Source

Identifiers

PMID: 15767359
DOI: 10.1158/1055-9965.EPI-04-0538

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15767359-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Haplotype-phenotype relationships of paraoxonase-1.PMID 15767359Read ↗

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Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression.Semantic proximity Read ↗

PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genesSemantic proximity Read ↗

Genetic and environmental determinants of the PON-1 phenotype.Semantic proximity Read ↗

Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns.Semantic proximity Read ↗

Increased influence of genetic variation on PON1 activity in neonates.Semantic proximity Read ↗

Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease.Semantic proximity Read ↗

Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population.Semantic proximity Read ↗

Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.Semantic proximity Read ↗

Determination of paraoxonase 1 status and genotypes at specific polymorphic sites.Semantic proximity Read ↗

Differential effect of ABCB1 haplotypes on promoter activity.Semantic proximity Read ↗

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