Article
Performance deficits of mGluR8 knockout mice in learning tasks: the effects of null mutation and the background genotype.
Neuropharmacology - 1 Aug 2002
Gerlai R, Adams B, Fitch T, Chaney S, Baez M
Abstract excerpt
mGluR8 is a G-protein coupled metabotropic glutamate receptor expressed in the mammalian brain. Members of the mGluR family have been shown to be modulators of neural plasticity and learning and memory. Here we analyze the consequences of a null mutation at the mGluR8 gene locus generated using homologous recombination in embryonic stem cells by comparing the learning performance of the mutants with that of wild...
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