Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome.

Nature genetics - 8 Jan 2012

Samaco Rodney C, Mandel-Brehm Caleigh, McGraw Christopher M, Shaw Chad A, McGill Bryan E, Zoghbi Huda Y

Abstract excerpt

Genomic duplications spanning Xq28 are associated with a spectrum of phenotypes, including anxiety and autism. The minimal region shared among affected individuals includes MECP2 and IRAK1, although it is unclear which gene when overexpressed causes anxiety and social behavior deficits. We report that doubling MECP2 levels causes heightened anxiety and autism-like features in mice and alters the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corticosterone

Share to Corticotropin-Releasing Hormone

Share to Gene Duplication

Share to Methyl-CpG-Binding Protein 2

Share to Receptors, Opioid, mu

Share to Social Behavior

Source

Open in PubMed Open full text

Identifiers

PMID: 22231481
DOI: 10.1038/ng.1066
PMCID: PMC3267865

Genes

MECP2
IRAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome.PMID 22231481Read ↗

Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.Semantic proximity Read ↗

MeCP2 dysfunction in humans and mice.Semantic proximity Read ↗

Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome.Semantic proximity Read ↗

Heterozygosity of murine Crkl does not recapitulate behavioral dimensions of human 22q11.2 hemizygosity.Semantic proximity Read ↗

Applying the ethoexperimental approach to neurodevelopmental syndrome research reveals exaggerated defensive behavior in Mecp2 mutant mice.Semantic proximity Read ↗

Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism.Semantic proximity Read ↗

Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality in mice.Semantic proximity Read ↗

Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett SyndromeSemantic proximity Read ↗

Expanding the clinical picture of the MECP2 Duplication syndrome.Semantic proximity Read ↗

Sex-specific stress-related behavioral phenotypes and central amygdala dysfunction in a mouse model of 16p11.2 microdeletionSemantic proximity Read ↗

Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males.Semantic proximity Read ↗

Genetic Reduction or Negative Modulation of mGlu7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.