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Article

Zebrafish mecp2 null-mutation increases anxiety and cortisol levels but no change in adult social preference and larval chemically-induced hyperlocomotion.

BMC neuroscience - 1 Jul 2025

Shams Soaleha, Cronell Pierre, Landin Jenny, Pietri Thomas, Gimdal Adrian Ekehorn, Kettunen Petronella, Westberg Lars

Abstract excerpt

BACKGROUND: Methyl CpG binding protein 2 (MECP2) is an essential global modulator of transcription and mutations in MECP2 are the most common cause of Rett syndrome, an X-linked neurodevelopmental disorder. Patients diagnosed with Rett syndrome have increased risk for epilepsy as well as problems with anxiety and social communication. Using the zebrafish mecp2Q63X line, this study aimed to increase our...

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Source

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Identifiers

PMID: 40596833
DOI: 10.1186/s12868-025-00946-8
PMCID: PMC12220008

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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