Article
Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model.
The Journal of pharmacology and experimental therapeutics - 1 Feb 2018
Christou Helen, Hudalla Hannes, Michael Zoe, Filatava Evgenia J, Li Jun, Zhu Minglin, Possomato-Vieira Jose S, Dias-Junior Carlos, Kourembanas Stella, Khalil Raouf A
Abstract excerpt
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and, in turn, the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and we examined the underlying mechanisms in the Sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with Sugen (20 mg/kg s.c.) and exposed to hypoxia (9% O2) for 3 weeks, followed by 4 weeks in...
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