Article
Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.
PloS one - 1 Jan 2015
Otsuki Shoichiro, Sawada Hirofumi, Yodoya Noriko, Shinohara Tsutomu, Kato Taichi, Ohashi Hiroyuki, Zhang Erquan, Imanaka-Yoshida Kyoko, Shimpo Hideto, Maruyama Kazuo, Komada Yoshihiro, Mitani Yoshihide
Abstract excerpt
We tested the hypothesis that phenotypically modulated smooth muscle cells (SMCs) and related inflammation are associated with the progression of experimental occlusive pulmonary vascular disease (PVD). Occlusive PVD was induced by combined exposure to a vascular endothelial growth factor receptor tyrosine kinase inhibitor Sugen 5416 and hypobaric hypoxia for 3 weeks in rats, which were then returned to ambient...
Topics
- Animals
- Arterial Occlusive Diseases
- Disease Models, Animal
- Fibrosis
- Gene Expression
- Hemodynamics
- Hypertension, Pulmonary
- Hypoxia
- Inflammation
- Macrophages