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Article

Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2014

Osei-Owusu Patrick, Knutsen Russell H, Kozel Beth A, Dietrich Hans H, Blumer Kendall J, Mecham Robert P

Abstract excerpt

Elastin (Eln) insufficiency in mice and humans is associated with hypertension and altered structure and mechanical properties of large arteries. However, it is not known to what extent functional or structural changes in resistance arteries contribute to the elevated blood pressure that is characteristic of Eln insufficiency. Here, we investigated how Eln insufficiency affects the structure and function of the...

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Identifiers

PMID: 24414067
DOI: 10.1152/ajpheart.00601.2013
PMCID: PMC3949062

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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