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Article

Sildenafil inhibits hypoxia-induced pulmonary hypertension.

Circulation - 24 Jul 2001

Zhao L, Mason N A, Morrell N W, Kojonazarov B, Sadykov A, Maripov A, Mirrakhimov M M, Aldashev A, Wilkins M R

Abstract excerpt

BACKGROUND: This study investigated the effect of the phosphodiesterase 5 inhibitor sildenafil on the pulmonary vascular response to hypoxia in humans and mice. METHODS AND RESULTS: In a randomized, double-blind study, sildenafil 100 mg or placebo was given orally to 10 healthy volunteers 1 hour...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11468204
DOI: 10.1161/hc2901.093117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11468204-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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