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Article

Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia.

The American journal of pathology - 1 Mar 2009

Dempsey Edward C, Wick Marilee J, Karoor Vijaya, Barr Erica J, Tallman Dustin W, Wehling Carol A, Walchak Sandra J, Laudi Sven, Le Mysan, Oka Masahiko, Majka Susan, Cool Carlyne D, Fagan Karen A, Klemm Dwight J, Hersh Louis B, Gerard Norma P, Gerard Craig, Miller York E

Abstract excerpt

Neprilysin is a transmembrane metalloendopeptidase that degrades neuropeptides that are important for both growth and contraction. In addition to promoting carcinogenesis, decreased levels of neprilysin increases inflammation and neuroendocrine cell hyperplasia, which may predispose to vascular remodeling. Early pharmacological studies showed a decrease in chronic hypoxic pulmonary hypertension with neprilysin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19234135
DOI: 10.2353/ajpath.2009.080345
PMCID: PMC2665740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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