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Article

Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.

American journal of physiology. Renal physiology - 1 Apr 2018

Watanabe Atsushi, Marumo Takeshi, Kawarazaki Wakako, Nishimoto Mitsuhiro, Ayuzawa Nobuhiro, Ueda Kohei, Hirohama Daigoro, Tanaka Toshiya, Yagi Shintaro, Ota Satoshi, Nagae Genta, Aburatani Hiroyuki, Kumagai Hiroo, Fujita Toshiro

Abstract excerpt

Epigenetic abnormalities have been suggested to mediate metabolic memory observed in diabetic complications. We have shown that epigenetic alterations may induce persistent phenotypic changes in the proximal tubules of the diabetic kidneys. In this study, we show that pregnane X receptor (PXR), a xenobiotic nuclear receptor, is epigenetically altered and upregulated and may have a possible function in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29212764
DOI: 10.1152/ajprenal.00390.2017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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