Article
Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model.
Disease models & mechanisms - 1 Sept 2012
Martínez-García Cristina, Izquierdo Adriana, Velagapudi Vidya, Vivas Yurena, Velasco Ismael, Campbell Mark, Burling Keith, Cava Fernando, Ros Manuel, Oresic Matej, Vidal-Puig Antonio, Medina-Gomez Gema
Abstract excerpt
Individuals with metabolic syndrome are at high risk of developing chronic kidney disease (CKD) through unclear pathogenic mechanisms. Obesity and diabetes are known to induce glucolipotoxic effects in metabolically relevant organs. However, the pathogenic role of glucolipotoxicity in the aetiolo...
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