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DNA methylation and the potential role of demethylating agents in prevention of progressive chronic kidney disease

24 Apr 2018

Abstract excerpt

Chronic kidney disease (CKD) is a global epidemic, and its major risk factors include obesity and type 2 diabetes. Obesity not only promotes metabolic dysregulation and the development of diabetic kidney disease but also may independently lead to CKD by a variety of mechanisms, including endocrine and metabolic dysfunction, inflammation, oxidative stress, altered renal hemodynamics, and lipotoxicity. Deleterious...

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PMID: 29688808
DOI: 10.1096/fj.201800205r

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