Article
Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes.
American journal of physiology. Renal physiology - 1 Sept 2024
Marumo Takeshi, Yoshida Naoto, Inoue Noriko, Yamanouchi Masayuki, Ubara Yoshifumi, Urakami Shinji, Fujii Takeshi, Takazawa Yutaka, Ohashi Kenichi, Kawarazaki Wakako, Nishimoto Mitsuhiro, Ayuzawa Nobuhiro, Hirohama Daigoro, Nagae Genta, Fujimoto Mao, Arai Eri, Kanai Yae, Hoshino Junichi, Fujita Toshiro
Abstract excerpt
Epigenetic mechanisms are considered to contribute to diabetic nephropathy by maintaining memory of poor glycemic control during the early stages of diabetes. However, DNA methylation changes in the human kidney are poorly characterized, because of the lack of cell type-specific analysis. We examined DNA methylation in proximal tubules (PTs) purified from patients with diabetic nephropathy and identified...
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