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Article

Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.

Nature communications - 1 Jan 2013

Zhang Yong-Hong, Zhao Yan, Li Ning, Peng Yan-Chun, Giannoulatou Eleni, Jin Rong-Hua, Yan Hui-Ping, Wu Hao, Liu Jin-Hua, Liu Ning, Wang Da-Yan, Shu Yue-Long, Ho Ling-Pei, Kellam Paul, McMichael Andrew, Dong Tao

Abstract excerpt

The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild...

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Identifiers

PMID: 23361009
DOI: 10.1038/ncomms2433
PMCID: PMC3562464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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