Article
Promoter haplotypes of interleukin-10 gene linked to cortex plasticity in subjects with risk of Alzheimer's disease.
NeuroImage. Clinical - 1 Jan 2018
Bai Feng, Xie Chunming, Yuan Yonggui, Shi Yongmei, Zhang Zhijun
Abstract excerpt
The Alzheimer's disease (AD) aetiologic event is associated with brain inflammatory processes. In this study, we consider a haplotype of the IL-10 gene promoter region, - 1082A/- 819 T/- 592A (ATA haplotype), which is an additive and independent genetic risk factor for AD. Episodic memory change is the most striking cognitive alteration in AD. It remains unclear whether episodic memory networks can be affected by...
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