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Article

Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults.

Archives of general psychiatry - 1 Aug 2012

Nichols Lisa M, Masdeu Joseph C, Mattay Venkata S, Kohn Philip, Emery Matthew, Sambataro Fabio, Kolachana Bhaskar, Elvevåg Brita, Kippenhan Shane, Weinberger Daniel R, Berman Karen F

Abstract excerpt

CONTEXT: Although the apolipoprotein E (APOE) ϵ4 allele is a major genetic risk factor for late-onset Alzheimer disease, its effect on hippocampal function during episodic memory is controversial because studies have yielded mixed results. The age of the studied cohorts may contribute to this apparent inconsistency: activation for ϵ4 carriers tends to be increased in studies of older adults but decreased in some...

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Source

Identifiers

PMID: 22868934
DOI: 10.1001/archgenpsychiatry.2011.1893

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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