Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer's disease.

doi:10.1186/s12974-017-0791-z

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Article

Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer's disease.

Journal of neuroinflammation - 18 Jan 2017

Huang Chi-Wei, Hsu Shih-Wei, Tsai Shih-Jen, Chen Nai-Ching, Liu Mu-En, Lee Chen-Chang, Huang Shu-Hua, Chang Weng-Neng, Chang Ya-Ting, Tsai Wan-Chen, Chang Chiung-Chih

Abstract excerpt

BACKGROUND: Inflammatory processes play a pivotal role in the degenerative process of Alzheimer's disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 beta gene has been significantly associated with differences in the secretory capacity of interleukin-1 beta. In this study, we investigated whether this functional polymorphism mediates the brain...

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PMID: 28100246
DOI: 10.1186/s12974-017-0791-z
PMCID: PMC5242022

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