Article
Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease.
Neuroscience letters - 12 Feb 2004
Scassellati Catia, Zanardini Roberta, Squitti Rosanna, Bocchio-Chiavetto Luisella, Bonvicini Cristian, Binetti Giuliano, Zanetti Orazio, Cassetta Emanuele, Gennarelli Massimo
Abstract excerpt
Clinical and immunopathological evidence support a potential role of the pro- and anti-inflammatory cytokine network in neurodegeneration of Alzheimer's disease (AD). Moreover, association studies suggest a possible involvement of cytokine-related genes in the susceptibility to sporadic AD. Since conflicting results are associated with the pro-inflammatory pathway, we investigated a putative effect of the...
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