Article
The E3 Ubiquitin Ligase RNF7 Negatively Regulates CARD14/CARMA2sh Signaling.
International journal of molecular sciences - 1 Dec 2017
Telesio Gianluca, Scudiero Ivan, Pizzulo Maddalena, Mazzone Pellegrino, Zotti Tiziana, Voccola Serena, Polvere Immacolata, Vito Pasquale, Stilo Romania
Abstract excerpt
The three CARD-containing MAGUK (CARMA) proteins function as scaffolding molecules that regulate activation of the pro-inflammatory transcription factor NF-κB. Recently, mutations in CARMA2 have been linked to psoriasis susceptibility due to their acquired altered capacity to activate NF-κB. By means of two-hybrid screening with yeast, we identified RING finger protein 7 (RNF7) as an interactor of CARMA2. We...
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