Article
Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation.
The American journal of pathology - 1 Sept 2015
Watt Stephen A, Purdie Karin J, den Breems Nicoline Y, Dimon Michelle, Arron Sarah T, McHugh Angela T, Xue Dylan J, Dayal Jasbani H S, Proby Charlotte M, Harwood Catherine A, Leigh Irene M, South Andrew P
Abstract excerpt
NF-κB signaling plays a crucial role in regulating proliferation and differentiation in the epidermis. Alterations in the NF-κB pathway can lead to skin pathologies with a significant burden to human health such as psoriasis and cutaneous squamous cell carcinoma (cSCC). Caspase recruitment domain (CARD)-containing scaffold proteins are key regulators of NF-κB signaling by providing a link between membrane...
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