Article
Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.
The Biochemical journal - 15 Jun 2016
Howes Ashleigh, O'Sullivan Paul A, Breyer Felix, Ghose Ashavari, Cao Li, Krappmann Daniel, Bowcock Anne M, Ley Steven C
Abstract excerpt
Inherited and de novo mutations in the CARD14 gene promote the development of psoriasis, an inflammatory disease of the skin. Caspase recruitment domain-containing protein 14 (CARD14) is a member of the CARMA protein family that includes the structurally related CARD11 adaptor that mediates NF-κB activation by antigen receptors. We investigated the mechanism by which CARD14 mutation in psoriasis activates NF-κB....
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