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Article

Computational Identification of RNF114 nsSNPs with Potential Roles in Psoriasis and Immune Dysregulation.

Medical sciences (Basel, Switzerland) - 16 Sept 2025

Aldoseri Ghalia Mahfod, Alwabran Arwa Ibrahim, Aldoseri Ghanem Mahfod, Aldoseri Mobarak Mahfod, Kamal Ebtihal

Abstract excerpt

BACKGROUND: RNF114 gene encodes an E3 ubiquitin ligase involved in immune signaling and regulation of inflammation. Genetic variants, particularly nonsynonymous single-nucleotide polymorphisms (nsSNPs), may interfere with protein function and cause immune diseases such as psoriasis. Although significant, the structural and functional impact of RNF114 nsSNPs is not well understood. METHODS: We used comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40981192
DOI: 10.3390/medsci13030194
PMCID: PMC12452777

Genes

RNF114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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