Article
CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses.
Nature immunology - 1 Jun 2018
Xu Xia, Xu Jin-Fu, Zheng Guoxing, Lu Hai-Wen, Duan Jie-Lin, Rui Wei, Guan Jian-Hong, Cheng Li-Qing, Yang Dan-Dan, Wang Ming-Chao, Lv Quan-Zhen, Li Jian-Xiong, Zhao Xueqiang, Chen Chun-Xia, Shi Peng, Jia Xin-Ming, Lin Xin
Abstract excerpt
The adaptor CARD9 functions downstream of C-type lectin receptors (CLRs) for the sensing of microbial infection, which leads to responses by the TH1 and TH17 subsets of helper T cells. The single-nucleotide polymorphism rs4077515 at CARD9 in the human genome, which results in the substitution S12N (CARD9S12N), is associated with several autoimmune diseases. However, the function of CARD9S12N has remained unknown....
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