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Article

Clinical and Genetic Heterogeneity of CARD14 Mutations in Psoriatic Skin Disease

16 Oct 2018

Abstract excerpt

The CARD: BCL10: MALT1 (CBM) complex is an essential signalling node for maintaining both innate and adaptive immune responses. CBM complex components have gained considerable interest due to the dramatic effects of associated mutations in causing severe lymphomas, immunodeficiencies, carcinomas and inflammatory disease. While MALT1 and BCL10 are ubiquitous proteins, the CARD-containing proteins differ in their...

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Identifiers

PMID: 30386326
DOI: 10.3389/fimmu.2018.02239

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