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Article

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

1 Jul 2018

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 29980436
DOI: 10.1016/j.immuni.2018.05.012

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Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17APMID 29980436Read ↗

Psoriasis Plays a Wild CARD.Semantic proximity Read ↗

Autosomal dominant familial generalized pustular psoriasis caused by a CARD14 mutation.Semantic proximity Read ↗

CARD14 alterations and psoriasis: are psoriasis and related disorders genetic autoinflammatory diseases?Semantic proximity Read ↗

Loss-of-function mutations in caspase recruitment domain-containing protein 14 (CARD14) are associated with a severe variant of atopic dermatitisSemantic proximity Read ↗

Clinical and Genetic Heterogeneity of CARD14 Mutations in Psoriatic Skin DiseaseSemantic proximity Read ↗

PSORS2 is due to mutations in CARD14.Semantic proximity Read ↗

Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European PatientsSemantic proximity Read ↗

CARD14 mutations may predict response to antitumour necrosis factor-α therapy in psoriasis: a potential further step towards personalized medicine.Semantic proximity Read ↗

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.Semantic proximity Read ↗

Terbinafine-induced generalized pustular psoriasis in a patient carrying CARD14 mutation.Semantic proximity Read ↗

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.Semantic proximity Read ↗

IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model miceSemantic proximity Read ↗

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