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Article

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A

1 Jul 2018

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Autoimmune Bullous Skin Diseases
Mast cells and histamine
Psoriasis: Treatment and Pathogenesis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29980436
DOI: 10.1016/j.immuni.2018.05.012

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Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17APMID 29980436Read ↗

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Palmoplantar Pustular Psoriasis Is Associated with Missense Variants in CARD14, but Not with Loss-of-Function Mutations in IL36RN in European PatientsSemantic proximity Read ↗

CARD14 mutations may predict response to antitumour necrosis factor-α therapy in psoriasis: a potential further step towards personalized medicine.Semantic proximity Read ↗

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Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.Semantic proximity Read ↗

IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model miceSemantic proximity Read ↗

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