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Article

AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.

Nucleic acids research - 1 Dec 2012

Gaetani Massimiliano, Matafora Vittoria, Saare Mario, Spiliotopoulos Dimitrios, Mollica Luca, Quilici Giacomo, Chignola Francesca, Mannella Valeria, Zucchelli Chiara, Peterson Pärt, Bachi Angela, Musco Giovanna

Abstract excerpt

Mutations in autoimmune regulator (AIRE) gene cause autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. AIRE is expressed in thymic medullary epithelial cells, where it promotes the expression of peripheral-tissue antigens to mediate deletional tolerance, thereby preventing self-reactivity. AIRE contains two plant homeodomains (PHDs) which are sites of pathological mutations. AIRE-PHD fingers are...

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PMID: 23074189
DOI: 10.1093/nar/gks933
PMCID: PMC3526288

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AIRE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.PMID 23074189Read ↗

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