Article
The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.
EMBO reports - 1 Jun 2016
Afonina Inna S, Van Nuffel Elien, Baudelet Griet, Driege Yasmine, Kreike Marja, Staal Jens, Beyaert Rudi
Abstract excerpt
Mutations in CARD14 have recently been linked to psoriasis susceptibility. CARD14 is an epidermal regulator of NF-κB activation. However, the ability of CARD14 to activate other signaling pathways as well as the biochemical mechanisms that mediate and regulate its function remain to be determined. Here, we report that in addition to NF-κB signaling, CARD14 activates p38 and JNK MAP kinase pathways, all of which...
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