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Article

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.

The Journal of investigative dermatology - 1 Mar 2017

Van Nuffel Elien, Schmitt Anja, Afonina Inna S, Schulze-Osthoff Klaus, Beyaert Rudi, Hailfinger Stephan

Abstract excerpt

Mutations in caspase recruitment domain-containing protein 14(CARD14) have been linked to susceptibility to psoriasis. CARD14 is an intracellular scaffold protein that regulates proinflammatory gene expression. Recent studies have offered novel insights into the mechanisms of CARD14-mediated signaling in keratinocytes and the molecular impact of psoriasis-associated CARD14 mutations. CARD14 forms a signaling...

Topics

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Psoriasis
Neoplasm Proteins
Adaptor Proteins, Signal Transducing
CARD Signaling Adaptor Proteins
Caspases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanylate Cyclase

Membrane Proteins

Source

Identifiers

PMID: 27939769
DOI: 10.1016/j.jid.2016.09.031

Genes

CARD14
MALT1
BCL10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis.PMID 27939769Read ↗

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes.Semantic proximity Read ↗

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.Semantic proximity Read ↗

Clinical and Genetic Heterogeneity of CARD14 Mutations in Psoriatic Skin DiseaseSemantic proximity Read ↗

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Revealing the intricacies: A comprehensive study of the CARD14 gene in Psoriatic patients of Indian descentSemantic proximity Read ↗

PSORS2 is due to mutations in CARD14.Semantic proximity Read ↗

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17ASemantic proximity Read ↗

Loss-of-function mutations in caspase recruitment domain-containing protein 14 (CARD14) are associated with a severe variant of atopic dermatitisSemantic proximity Read ↗

Psoriasis Plays a Wild CARD.Semantic proximity Read ↗

CARD14 expression in dermal endothelial cells in psoriasis.Semantic proximity Read ↗

Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent MannerSemantic proximity Read ↗

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