Article
A<i>Dictyostelium</i>Homologue of WASP Is Required for Polarized F-Actin Assembly during Chemotaxis
24 Feb 2005
Abstract excerpt
The actin cytoskeleton controls the overall structure of cells and is highly polarized in chemotaxing cells, with F-actin assembled predominantly in the anterior leading edge and to a lesser degree in the cell's posterior. Wiskott-Aldrich syndrome protein (WASP) has emerged as a central player in controlling actin polymerization. We have investigated WASP function and its regulation in chemotaxing Dictyostelium...
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