Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2017

Qin Na, Wang Cheng, Zhu Meng, Lu Qun, Ma Zijian, Huang Mingtao, Dai Juncheng, Ma Hongxia, Jin Guangfu, Hu Zhibin, Shen Hongbing

Abstract excerpt

OBJECTIVES: The polymorphic major histocompatibility complex (MHC) plays a vital role in the immune system and drives predisposition to multiple cancers. A number of lung cancer-related genetic variants in the MHC have been identified in recent genome-wide association studies; however, the causal variants remain unclear. MATERIALS AND METHODS: In the present study, we conducted a large-scale fine-mapping study of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to Disease Susceptibility

Share to Lung Neoplasms

Share to Major Histocompatibility Complex

Share to Proportional Hazards Models

Share to Quantitative Trait Loci

Source

Identifiers

PMID: 29191591
DOI: 10.1016/j.lungcan.2017.08.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer.PMID 29191591Read ↗

Frequency changes in HLA-I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD-L1 expression.Semantic proximity Read ↗

Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.Semantic proximity Read ↗

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.Semantic proximity Read ↗

An immunogenetic basis for lung cancer risk.Semantic proximity Read ↗

Association of HLA diversity with the risk of 25 cancers in the UK Biobank.Semantic proximity Read ↗

Genetic variants in the human leukocyte antigen region and survival of Chinese patients with non-small cell lung carcinoma.Semantic proximity Read ↗

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.Semantic proximity Read ↗

Variations in the MHC region confer risk to esophageal squamous cell carcinoma on the subjects from high-incidence area in northern China.Semantic proximity Read ↗

Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese.Semantic proximity Read ↗

Effect of HLA-B-associated transcript 3 polymorphisms on lung cancer risk: a meta-analysis.Semantic proximity Read ↗

Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.Semantic proximity Read ↗

Germline HLA heterozygosity is associated with decreased lung cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.