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Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.

Communications biology - 11 Dec 2020

Ning Lvwen, Ko Josephine Mun-Yee, Yu Valen Zhuoyou, Ng Hoi Yan, Chan Candy King-Chi, Tao Lihua, Lam Shiu-Yeung, Leong Merrin Man-Long, Ngan Roger Kai-Cheong, Kwong Dora Lai-Wan, Lee Anne Wing-Mui, Ng Wai-Tong, Cheng Ashley, Tung Stewart, Lee Victor Ho-Fun, Lam Ka-On, Kwan Chung-Kong, Li Wing-Sum, Yau Stephen, Bei Jin-Xin, Lung Maria Li

Abstract excerpt

Despite pronounced associations of major histocompatibility complex (MHC) regions with nasopharyngeal carcinoma (NPC), causal variants underlying NPC pathogenesis remain elusive. Our large-scale comprehensive MHC region deep sequencing study of 5689 Hong Kong Chinese identifies eight independent NPC-associated signals and provides mechanistic insight for disrupted transcription factor binding, altering target...

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Identifiers

PMID: 33311639
DOI: 10.1038/s42003-020-01487-y
PMCID: PMC7733486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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