Article
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.
Nature communications - 9 Aug 2016
Shiraishi Kouya, Okada Yukinori, Takahashi Atsushi, Kamatani Yoichiro, Momozawa Yukihide, Ashikawa Kyota, Kunitoh Hideo, Matsumoto Shingo, Takano Atsushi, Shimizu Kimihiro, Goto Akiteru, Tsuta Koji, Watanabe Shun-Ichi, Ohe Yuichiro, Watanabe Yukio, Goto Yasushi, Nokihara Hiroshi, Furuta Koh, Yoshida Akihiko, Goto Koichi, Hishida Tomoyuki, Tsuboi Masahiro, Tsuchihara Katsuya, Miyagi Yohei, Nakayama Haruhiko, Yokose Tomoyuki, Tanaka Kazumi, Nagashima Toshiteru, Ohtaki Yoichi, Maeda Daichi, Imai Kazuhiro, Minamiya Yoshihiro, Sakamoto Hiromi, Saito Akira, Shimada Yoko, Sunami Kuniko, Saito Motonobu, Inazawa Johji, Nakamura Yusuke, Yoshida Teruhiko, Yokota Jun, Matsuda Fumihiko, Matsuo Keitaro, Daigo Yataro, Kubo Michiaki, Kohno Takashi
Abstract excerpt
Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3...
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