Article
Frequency changes in HLA-I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD-L1 expression.
Thoracic cancer - 1 Jul 2023
Wu Xuanpeng, Wang Hao, Xue Fei, Jiang Tao, Chen Nanzheng, Wang Tianju, Zhang Yong, Zhang Guangjian, Fu Junke, Wu Qifei
Abstract excerpt
BACKGROUND: The aim of the study was to investigate differences in HLA-I alleles between lung adenocarcinoma patients and healthy controls and determine their association with PD-L1 expression and tumor mutational burden (TMB) to understand the mechanism underlying lung adenocarcinoma susceptibility. METHODS: Differences in HLA allele frequencies between the two groups were analyzed in a case-control study. PD-L1...
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