Germline HLA heterozygosity is associated with decreased lung cancer risk.

doi:10.1016/j.xhgg.2026.100567

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Article

Germline HLA heterozygosity is associated with decreased lung cancer risk.

HGG advances - 9 Apr 2026

Tan Taotao, Shaw Vikram R, Byun Jinyoung, Lee Hyun-Sung, Han Younghun, Li Yafang, Hung Rayjean J, Christiani David C, Wang Xin-An, Johansson Mattias, Xiao Xiangjun, Zaridze David, Bojesen Stig Egil, Shete Sanjay, Albanes Demetrios, Aldrich Melinda C, Tardon Adonina, Fernandez-Tardon Guillermo, Le Marchand Loïc, Rennert Gad, Bickeböller Heike, Wichmann H-Erich, Risch Angela, Field John K, Davies Michael, Woll Penella, Kiemeney Lambertus A, Haugen Aage, Zienolddiny Shanbeh, Lam Stephen, Johansson Mikael, Grankvist Kjell, Schabath Matthew B, Andrew Angeline, Lazarus Philip, Arnold Susanne M, Zhu Dakai, Landi Maria Teresa, McKay James, Amos Christopher, Cheng Chao

Abstract excerpt

Heterozygosity at human leukocyte antigen (HLA) loci may improve lung cancer immunosurveillance by increasing recognition of the tumor by the immune system. Previous studies utilizing data from population-level biobanks, such as the United Kingdom Biobank and FinnGen, have identified an association between germline HLA class II (HLA-II) heterozygosity and reduced lung cancer risk in smokers. In the present study,...

Topics

Humans
Lung Neoplasms
Genetic Predisposition to Disease
Heterozygote
Female
Case-Control Studies
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Smoking

HLA Antigens

Risk Factors

Alleles

Middle Aged

Aged

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Identifiers

PMID: 41530975
DOI: 10.1016/j.xhgg.2026.100567
PMCID: PMC12860938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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